There are considerable uncertainties in the magnitude of immune escape potential of Omicron. Infections are expected in vaccinated persons, albeit in a small and predictable proportion
Increasing cases, regardless of a change in severity, may pose overwhelming demands on health care systems and may lead to increased morbidity and mortality. The impact on vulnerable populations would be substantial, particularly in countries with low vaccination coverage
Omicron has an unprecedented number of spike mutations, some of which are concerning for their potential impact on the trajectory of the pandemic. The overall global risk related to the new variant is assessed as very high